Wrong parasite, wrong host? How Plasmodium falciparum erythrocyte membrane protein 1 expression and the host’s innate immune response combine to influence the inflammatory response to malaria in vitro and in vivo. Implications for severe malaria

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1061993

Funding Status
Closed

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Funded Activity Summary

One factor that determines whether some children die of malaria is the type of protein that the parasite expresses on the red blood cell, to help it stick in blood vessels. Our new data suggests that some proteins stimulate excessive host immune response, possibly leading to severe malaria. People's immne response to malaria varies too, and we will discover whether severe malaria occurs when a dangerous parasite strain infects a susceptible host causing an excessive immune response, harming the child.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $707,821.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Parasitology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Plasmodium falciparum | antigenic variation | inflammatory cytokines | innate immunity | malaria | monocyte/macrophage

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