Intron retention regulation in granulopoiesis and leukaemia

Funding Activity

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Funded Activity Summary

Our project will shed light on the development of white blood cells, and what goes wrong when they become cancerous. In particular we have uncovered an unexpected control mechanism of gene expression in these cells. This mechanism governs the specific removal of molecules involved in transmitting information in cells (mRNAs). By extending our research to a cancer of white blood cells called chronic myeloid leukaemia, we hope to provide new insights into its causes and discover targets for innovative drugs.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $574,419.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Haematological Tumours

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

RNA processing | alternative splicing | bioinformatics | haematological malignancy | haematopoiesis | mouse models | myeloid leukaemia | myelopoiesis | sequence analysis | transcriptional regulation