Manipulating the balance of effector and regulatory T cells to promote islet xenograft survival

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1061868

Funding Status
Closed

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Funded Activity Summary

Type 1 diabetes destroys the body’s insulin-producing cells (islets), resulting in high blood sugar levels and the prospect of devastating complications. Replacement of islets by transplantation is the only way to restore normal blood sugar control, but (i) is limited by the shortage of human donors and (ii) carries risks associated with anti-rejection drugs. This project aims to solve both problems by using humanized pigs as donors combined with a novel approach to inducing tolerance to the transplanted islets.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2018

Funding Scheme: Project Grants

Funding Amount: $1,542,601.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical and Health Sciences not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

antibody therapy | immunosuppression | islet xenotransplantation | transgenic animals | type 1 diabetes mellitus (insulin-dependent diabetes mellitus)

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