Characterising the topology and function of the human m5C RNA methylome

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1061551

Funding Status
Closed

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Funded Activity Summary

The role of the modified base 5-methylcytosine (m5C) as an epigenetic mark in DNA is well appreciated and intensely studied. By comparison, the cellular functions of the same base modification in RNA molecules, which function as working copies of the DNA genome, are poorly understood. This project will apply next generation sequencing technology to chart the occurrence of m5C in eukaryotic cellular RNAs and endeavour to unravel its function(s) in human biology and cancer.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2017

Funding Scheme: Project Grants

Funding Amount: $602,537.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Gene Expression (incl. Microarray and other genome-wide approaches)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

RNA metabolism | RNA processing | bioinformatics | cytosine methylation | epigenetics | eukaryotic gene expression | gene regulation | messenger RNA (mRNA) | protein synthesis | sequencing

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