OXPHOS upregulation to preserve vision in Leber's Hereditary Optic Neuropathy

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1061472

Funding Status
Closed

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Funded Activity Summary

Leber's Hereditary Optic Neuropathy (LHON) is a devastating blinding disease that preferentially affects young men. Sufferers have normal vision until teenage years or their twenties when a rapid loss of vision occurs that results in permanent blindness. It is caused by genetic changes in the mitochondrial DNA that we inherit from our mothers. The mitochondria are the cells' energy generators. We aim to use molecules similar to female hormones to boost energy as a new treatment to preserve vision in at-risk LHON individuals.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $496,874.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Ophthalmology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

mitochondrial DNA (mtDNA) | mitochondrial disease | mitochondrial respiration | optic atrophy | optic nerve | respiratory chain

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