An ace up their sleeve: characterisation of a novel family of drug efflux systems represented by the Acinetobacter AceI exporter

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1060895

Funding Status
Closed

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Funded Activity Summary

Chlorhexidine is widely used as an antiseptic in products such as skin washes, soaps, mouthwashes, disinfectants and preservatives. We have recently discovered a novel bacterial protein which pumps chlorhexidine out of bacterial cells to make them resistant to this antiseptic agent. This proposal aims to understand this resistance mechanism and to find inhibitors which could be applied in clinical settings to augment the activity of chlorhexidine.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2017

Funding Scheme: Project Grants

Funding Amount: $400,286.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Bacteriology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

drug resistance | drug transport | molecular microbiology | multidrug resistance | pathogenic bacteria

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