Vesicular trafficking pathways underpinning neuronal secretion and survival

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1060075

Funding Status
Closed

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Funded Activity Summary

Plethora of diseases of the nervous system are caused by defects in vesicular trafficking including neurodegenerative diseases such as Alzheimer’s disease. I will explore the mechanisms underpinning synaptic vesicular trafficking using novel super resolution techniques and reveal the how secretory vesicles traffic to the plasma membrane, undergo exocytosis, and recycle. I will also explain how in the crowded environment of the presynaptic terminals, retrograde cargoes are transported back to the cell body thereby carrying survival signals.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2018

Funding Scheme: Research Fellowships

Funding Amount: $697,209.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

endocytosis | exocytosis | neurotoxins | neurotransmission | retrograde transport

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