Signalling pathways and fungal virulence – the inositol polyphosphate kinase pathway in Cryptococcus neoformans

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1058779

Funding Status
Closed

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Funded Activity Summary

Bloodstream fungal infections kill millions of people per year world-wide and are costly to treat. A potentially fruitful strategy for developing new, urgently-needed drugs to fight these infections, is to target signalling pathways, which in fungi, are essential for establishing infection. This proposal investigates how one such pathway, the inositolpolyphosphate kinase pathway, allows fungi to establish infection and will determine which components are suitable targets for drug development.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2017

Funding Scheme: Project Grants

Funding Amount: $545,189.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Microbiology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

animal model | cryptococcus | fungal pathogenesis | inositol phosphates | kinases | macrophages | phospholipases | signalling pathways | vesicle trafficking | virulence factors

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