Endosomal sorting of amyloid precursor protein in Alzheimer's disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1058734

Funding Status
Closed

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Funded Activity Summary

Alzheimer's Disease is a progressive neurological disorder and is the most common cause of dementia. Effective treatments are desperately needed, but none are currently available. The toxic amyloid peptide A? is central to disease pathology and is derived from breakdown of the Alzheimer’s amyloid precursor protein (APP). In this project we will examine the interactions between APP and the molecular machinery that controls its location in the cell and subsequent degradation.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2017

Funding Scheme: Project Grants

Funding Amount: $858,643.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Protein Trafficking

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Alzheimer disease | X-ray crystallography | amyloid precursor protein | endosomes | molecular neuroscience | protein interactions | protein trafficking

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