Mechanisms of Regulation of Ribosome Biogenesis and Function in Health and Disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1058586

Funding Status
Closed

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Funded Activity Summary

The PI3K/AKT signalling pathway drives many cancers and until recently was thought to do so by preventing cancer cell death. We have shown this pathway also regulates the synthesis of ribosomes, the cellular “factories” that make protein and by interfering with PI3K/AKT regulated ribosome synthesis, can kill cancer cells. We aim to establish the mechanisms underlying this regulation of ribosome synthesis and to test the hypothesis that ribosome biogenesis is a novel target for cancer treatment.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2018

Funding Scheme: Research Fellowships

Funding Amount: $631,010.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cancer cell biology | cell growth | haematological malignancy | ovarian cancer | pharmacogenomics | protein synthesis | signal transduction | squamous cell carcinoma | targeted therapy

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