Fibroblast Growth Factor Receptor 2c and human testicular dysgenesis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1058548

Funding Status
Closed

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Funded Activity Summary

Disorders of sex development (DSD) account for 7.5% of all birth defects. DSDs that affect testis development lead to testicular tumours, ambiguous genitalia, male-to-female sex reversal, and infertility. We have identified a novel protein (FGFR2) essential for testis development in mice and found the first FGFR2 mutations in DSD patients with testicular dysgenesis. Understanding the molecular action of FGFR2 will lead to improved diagnosis and management of DSD.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $611,197.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Developmental Genetics (incl. Sex Determination)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

fibroblast growth factor receptors (FGFR) | gonadal development | reproduction | signalling pathways | testis development | testosterone

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