The C-type lectin Mincle exemplifies a new mode of sterile inflammation in cardiovascular disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1057846

Funding Status
Closed

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Funded Activity Summary

This project investigates two of the life-changing cardiovascular events that most commonly impact on Australians today; Heart attack and Stroke. These diseases often leave individuals debilitated with a long recovery period, and for many people the event is fatal. We have shown that blocking the action of an immune component, "Mincle", reduces the inflammation associated with stroke, and improves recovery. This project looks at what Mincle does in brain and heart muscle, and why blocking Mincle protects cells from loss of oxygen.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2018

Funding Scheme: Project Grants

Funding Amount: $609,237.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Development, Proliferation and Death

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

autophagy | cardiac ischaemia | gene regulation | inflammation | lectins | macrophage biology | neuronal death

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