Targeting histone deacetylases 1 and 5 to reduce inflammation and bone loss in periodontitis.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1057835

Funding Status
Closed

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Funded Activity Summary

Bone loss and tooth loosening are serious complications in periodontitis. Despite the prevalence of this disease current treatments do not directly stop the bone loss. Our recent laboratory studies show inhibiting histone deacetylase (HDAC) activity with very low doses of inhibitors can effectively suppress this bone loss in periodontitis. This project aims to investigate specific targeting inhibitors of HDAC 1 and HDAC 5 to treat periodontitis by enhancing bone formation and reducing bone loss.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2017

Funding Scheme: Project Grants

Funding Amount: $536,745.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Periodontics

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

bone remodelling | histone deacetylase | osteoblast | osteoclast | periodontal disease

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