Chemical and structural biology validation of Lamin B1 as a new anti-cancer target

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1057805

Funding Status
Closed

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Funded Activity Summary

The validation of new anti-cancer targets is critical for the development of new therapies. We have discovered a small molecule that disrupt the function Lamin B1 during cell division and decreases tumour growth significantly in vivo. With this research proposal, we will investigate the role that Lamin B1 exerts during cell division and why interfering with this protein has such a profound impact on cancer cells.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $638,272.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medicinal and Biomolecular Chemistry not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cancer biology | cancer chemotherapy | cell division | chemotherapy | medicinal chemistry

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