Determining the potential for porcine foetal islet xenotransplantation.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/105704

Funding Status
Closed

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Funded Activity Summary

Tight glucose control by insulin injection minimises diabetic complications but restricts lifestyle. An alternative, pancreatic islet transplantation, is limited by donor shortage. With genetic technology, pig donor tissue is a feasible donor source. This project will use an inbred pig colony to assess long term foetal pig islet function in the absence of an immune response. It will outline the genetic characteristics of this pig colony and carefully catalogue the type, number and distribution of endogenous retroviruses within pig genes. It may provide a basis from which new strategies can be developed to overcome rejection. Ultimately a unique Australian resource will be developed which may provide unlimited islets for safe, large-scale transplantation of diabetics before they develop debilitating complications.

Funded Activity Details

Start Date: 01-01-2000

End Date: 01-01-2002

Funding Scheme: NHMRC Project Grants

Funding Amount: $351,660.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Dermatology

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

Diabetes | Islet transplantation | Organ failure | Transplantation | Xenotransplantation | Zoonoses | large animal surgical model | pig genetics | porcine retroviruses

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