Pro-apoptotic therapies for the treatment of Mycobacterium tuberculosis disease and latent infection

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1056282

Funding Status
Closed

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Funded Activity Summary

Programmed cell death has an important role in our ability to fight organisms. Upon infection, processes result in activation of death-inducing cascades, resulting in death of cell and pathogen. M. tuberculosis, an escalating health problem, has developed mechanisms to prevent this, leading to latency. This study, which uses mouse M.tb models, hypothesises that reversal of these mechanisms, using drugs currently in trial in leukaemia (ABT-737 & BV6), may lead to clearance of infection.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2016

Funding Scheme: Postgraduate Scholarships

Funding Amount: $140,949.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Innate Immunity

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

apoptosis | innate immunity | latency | mouse models | treatment evaluation | tuberculosis

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