The Pathway Linking Tau and APP in Neurodegeneration

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1054736

Funding Status
Closed

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Funded Activity Summary

Recently I co-discovered a novel relationship between the AlzheimerÍs amyloid precursor protein and tau, both of which play a role in regulating neuronal iron levels. I predict that multiple failures in iron-regulating systems could foster a toxic iron accumulation in brain, leading to the development of neurodegenerative diseases. I hope to gain a better understanding of their mechanism of action and propose that this pathway is a target for therapeutic intervention.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2017

Funding Scheme: Early Career Fellowships

Funding Amount: $312,085.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Neurology and Neuromuscular Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Alzheimer disease | Parkinson disease | amyloid precursor protein | disease mechanisms | drug targeting | frontotemporal dementia | iron overload | iron transport | microtubule associated protein (MAP)

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