Determining the Molecular Basis of Tumour Cell Multidrug Resistance: Structural and Functional Analysis of Breast Cancer Resistance Protein

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1053624

Funding Status
Closed

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Funded Activity Summary

Around 40% of human tumours develop resistance to chemotherapeutic drugs; a trait most commonly acquired by the increased expression of membrane proteins that remove a broad spectrum of molecules from the cell. This project aims to determine the structure of the human breast cancer resistance protein (BCRP), a protein of particular importance in this process. The structure of BCRP will provide a scaffold for the design of drugs aimed at inhibiting chemotherapy drug resistance.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2018

Funding Scheme: Early Career Fellowships

Funding Amount: $325,396.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Structural Biology (incl. Macromolecular Modelling)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

X-ray crystallography | breast cancer | drug resistance | membrane protein | membrane transport | protein structure | structural biology

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