The physiological and pathological role of the bile acid receptor TGR5 and its potential targeting for the treatment of intestinal motility disorders and visceral pain.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1053593

Funding Status
Closed

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Funded Activity Summary

Defects in the secretion of bile into the intestine cause digestive diseases, and abnormal circulating levels of bile acids induce profound itch and abnormal pain sensation. This project examines whether a cell-surface receptor (TGR5) produced by intestinal and sensory neurons mediates actions of bile acids on intestinal functions and pain. The project aims to define mechanisms of digestive and sensory disorders and identify new therapies for constipation, diarrhoea, and pain.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2016

Funding Scheme: Early Career Fellowships

Funding Amount: $311,860.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Autonomic Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

G protein-coupled receptors | bile acids | motility disorders | pain | secretion

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