Ubiquitin and SUMO DNA damage response signalling at deprotected telomeres during the cell cycle

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1053195

Funding Status
Closed

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Funded Activity Summary

Following genome damage cells stop the cell division process and initiate DNA repair. We discovered that at specific times during cell division his does not happen if the damage signals originate from the chromosome ends (i.e. “telomeres”). We anticipate this is necessary to prevent genomic instability in healthy cells and may be driving genomic instability in cancer cells. Experiments described here will elucidate the molecular mechanisms and biological significance of our observation.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $302,627.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell and Nuclear Division

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

DNA damage | cell culture | cell cycle control | cell cycle regulation | chromosomes | mitosis | molecular biology | telomeres | ubiquitination

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