Dissecting the interactions of antimalarial drugs with the two key determinants of drug resistance in the malaria parasite - the 'chloroquine resistance transporter' and the 'multidrug resistance transporter 1'

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1053082

Funding Status
Closed

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Funded Activity Summary

The malaria parasite is a single-celled organism which invades the red blood cells of its host. The aim of this fellowship is to study two proteins that are central to the parasite’s ability to evade the toxic effects of a number of drugs. The parasite's susceptibility to chloroquine, and other drugs, is altered by small changes in these proteins. This work will advance our understanding of the increasingly widespread phenomenon of antimalarial drug resistance, and of how it may be overcome.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2016

Funding Scheme: Career Development Fellowships

Funding Amount: $415,218.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Parasitology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Plasmodium falciparum | Xenopus oocytes | drug transport | malaria drug resistance | protein function | transporters

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