Evolutionary genomics approaches for studying acquisition of drug resistance in tumours

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1052904

Funding Status
Closed

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Funded Activity Summary

Chemotherapy often fails because some of the cells in tumour evolve resistance to the drugs the patient is given, causing relapse. We study how a tumour’s unstable genome and high rate of mutation drives its evolution by observing tumour cells in the laboratory as they evolve resistance to drugs and the genetic differences between resistant and sensitive cells. This work will help develop therapeutic strategies to prevent tumours from evolving resistance to chemotherapy.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2017

Funding Scheme: Early Career Fellowships

Funding Amount: $313,390.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Genomics

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

bioinformatics | cancer biology | cancer genetics | drug resistance | evolution | familial cancer | genomic instability | genomics | population genetics | statistical genetics

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