Hypothalamic oxexin-synthesizing neurons regulate the ultradian Basic Rest-Activity Cycle (BRAC); studies in transgenic rats and mice

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1051826

Funding Status
Closed

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Funded Activity Summary

In the hypothalamus region of the brain there is a group of neurons that synthesize a neuropeptide messenger called orexin. In humans, malfunction of orexin neurons results in narcolepsy (abnormal sleepiness) and in disordered metabolism resulting in obesity. Our experiments, conducted in genetically-modified rats and mice, will elucidate the manner in which the orexin neurons integrate our behaviour (eg eating) with our physiological state (eg body and brain temperature, arterial blood pressure).

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $588,418.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Central Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

arousal | autonomic nervous system | cardiovascular system | food intake | glucose homeostasis | hypothalamus | metabolism | neurotransmitters | temperature regulation | transgenic animals

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