Activation and suppression of oncogenic translocation by uracil-DNA glycosylases

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1051820

Funding Status
Closed

Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the .

Funded Activity Summary

The AID enzyme is implicated in cancer in B lymphocytes and prostate cells. AID causes DNA damage normally recognised by repair enzymes UNG and MutS?, among others. The repair processes these factors initiate involve a DNA break that, if incorrectly re-joined, destabilises the genome, causing cancer. Understanding the function of AID, UNG and MutS? in B cell lymphomas and prostate cancer will provide fundamental insights into cancer and may identify targets for new therapeutics.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $513,000.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Development, Proliferation and Death

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

B cells | DNA repair | lymphoma | mutation | prostate cancer | retrovirus | transgenic model | translocation

Related Links