Role of insulin-regulated aminopeptidase in ischemic stroke damage

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1051500

Funding Status
Closed

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Funded Activity Summary

Stroke is a neurovascular disease which is the leading cause of adult disability. A focus of our research group is to investigate the role of a protein called insulin-regulated aminopeptidase (IRAP) in ischemic stroke. We have shown a dramatic protection from ischemic brain damage in mice with deletion of the IRAP gene. The aims of this study are to explore the potential use of the newly developed IRAP inhibitors in protecting brain damage following ischemic stroke and to determine the role of IRAP in the pathophysiology of cerebral ischemia.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $499,219.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cardiology (incl. Cardiovascular Diseases)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

immune-mediated inflammation | ischaemia/reperfusion | neuroinflammation | neuroprotection | stroke

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