Physiological and pathological effects of oxidation on contractile function in skeletal muscle

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1051460

Funding Status
Closed

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Funded Activity Summary

Reactive oxygen molecules generated within muscle fibres in normal exercise and in pathological conditions, greatly affect muscle function by altering the responsiveness of the contractile proteins. This study investigates how various oxidative stresses affect particular reactive sites on key proteins controlling muscle contraction. The findings should identify key molecular changes involved in normal activity and the role oxidation plays in chronic muscle weakness in particular conditions.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $613,311.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Physiology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

excitation-contraction coupling | intracellular calcium | muscle damage | muscle disease | muscle fatigue | muscle fibre types | muscle physiology | muscle weakness | muscular dystrophy

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