Regulation of interleukin-1? activation in inflammatory diseases

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1051210

Funding Status
Closed

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Funded Activity Summary

IL-1? protein is required to combat infection but also contributes to inflammatory diseases, such as Rheumatoid arthritis and diabetes. Understanding how IL-1? is produced is therefore critical to the development of better therapeutics for these conditions. We have identified a new pathway involving the protein RIP3 that can cause IL-1? activation. This project will examine how this pathway is molecularly regulated and determine its importance in inflammatory disease models.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $624,429.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

acute inflammation | arthritis | cell death | innate immunity | interleukins (IL) | pancreatic necroinflammation | signalling pathways

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