Understanding the regulation of craniofacial development through control of chromatin and gene transcription

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1051078

Funding Status
Closed

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Funded Activity Summary

Cleft lip and palate are among the most common birth defects. Key genes regulating palate development are sensitive to disturbance by environmental factors. We use this system to comprehensively determine a molecular pathway that is at the interface between the environment and gene transcription. Knowledge gained in the project will draw a framework for our understanding of how environmental insults affect chromatin configuration and gene expression and will inform the basis of measures to prevent birth defects.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $616,372.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Epigenetics (incl. Genome Methylation and Epigenomics)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

chromatin | cleft lip and palate | developmental genetics | gene targeting | transcriptional regulation

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