A new function for an old enzyme: Src Protein Kinase directs excitotoxic neuronal death in stroke

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1050486

Funding Status
Closed

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Funded Activity Summary

In our previous investigation of how brain cells die in patients suffering from stroke, we found that stroke causes aberrant activation of an enzyme called Src in the affected brain cells. Furthermore, this aberrantly activated Src directs the brain cells to undergo cell death. Our proposal, which aims to decipher this neurotoxic mechanism of the aberrantly activated Src will benefit development of new therapeutic strategies to reduce brain damage in stroke patients.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $513,975.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Neurochemistry

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Src-family tyrosine kinases | cell death | cell survival | excitotoxicity | neuronal death | neuronal injury | neuroprotection | phospholipids | protein kinases | stroke

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