Role of the Area Postrema in Determining the Increased Cardiac Sympathetic Nerve Activity in Heart Failure

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1050268

Funding Status
Closed

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Funded Activity Summary

In heart failure there is a large increase in sympathetic nerve activity to the heart that has detrimental effects on the heart and can induce sudden death. The areas in the brain causing the increased nerve activity are unknown. We will investigate the role of the area postrema, which is a window to the brain for hormones in the blood. We have evidence that this brain site maintains the high level of nerve activity in heart failure, possibly stimulated by hormones circulating in the blood.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $489,912.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cardiology (incl. Cardiovascular Diseases)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

angiotensin II | central autonomic control | heart failure | lentivirus | sympathetic nervous system

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