Estimation and partitioning of the still-missing heritability for complex disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1050218

Funding Status
Closed

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Funded Activity Summary

We have pioneered the use of multi-marker statistical genetic methods in human genetics to elucidate the genetic architecture of complex traits, including common diseases. We have shown that between a third and a half of additive genetic variation is captured by common genetic variants, leaving two-thirds to a half truly ‘missing’. In this proposal we will test our hypothesis that the still-missing heritability is due to low frequency causal variants. Applications of genomic medicine require this fundamental knowledge to progress fully.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $291,856.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Quantitative Genetics (incl. Disease and Trait Mapping Genetics)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

complex genetic disease | genomics | immune system disorder | inflammatory bowel disease (IBD) | statistics

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