Modulation of Vegfc/Vegfr3 signaling at the extracellular matrix during embryonic lymphangiogenesis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1050138

Funding Status
Closed

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Funded Activity Summary

Lymphatic vessels play important roles in vascular diseases and cancer. However, we are yet to understand how they form during development and disease. We recently identified the gene CCBE1, essential for the formation of lymphatic vessels and responsible for lymphatic dysplasia in humans. This study aims to understand the molecular pathway in which CCBE1 acts. This work aims to characterize new molecular pathways in lymphatic vessels in order to identify new therapeutic targets in lymphatic disease and cancer.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $570,928.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Developmental Genetics (incl. Sex Determination)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

congenital disorders | lymphatics | vascular development | vascular endothelial growth factor (VEGF) | zebrafish

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