Bcl-2 proteins in tumourigenesis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1049949

Funding Status
Closed

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Funded Activity Summary

Cell survival and death are controlled by two processes known as apoptosis and autophagy. Apoptosis eliminates damaged cells whereas autophagy gets rid of faulty components in the cell. The Bcl-2 proteins regulate both processes. It is well established that dysfunctional Bcl-2 regulation leads to cancer. In this project, we aim to investigate if deregulated Bcl-2 control of autophagy also has a key role in cancer progression and to obtain a molecular picture of how this control is exerted.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $415,041.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cancer Cell Biology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Bcl-2 | apoptosis | autophagy | cancer | mouse models | mutagenesis | oncogenesis | structural biology | structure-based drug design | structure-function

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