Inhibiting tumour growth by targeting EphA3 and disrupting tumour stromal and vascular microenvironment

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1049942

Funding Status
Closed

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Funded Activity Summary

Tumours consist of cancer cells, tumour blood vessels and connective tissue, all of which are different to normal tissues. Many of the cells making up tumour vessels and connective tissue are recruited, during initial growth and subsequent spreading of tumours, from the bone marrow. Our research will examine the presence and function of the EphA3 receptor on these cells during tumour development and assess how our anti-EphA3 antibody inhibits tumour growth by targeting stroma and vasculature.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $645,136.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Molecular Targets

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Eph receptors | anti-tumour agents | antibody cancer therapy | bone marrow transplantation | cancer biology | cancer prevention | control of microvascular blood flow | control of tumour progression | neovascularisation | tumour-specific antigens

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