The mechanisms through which opiates cause gastrointestinal dysfunction

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1049730

Funding Status
Closed

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Funded Activity Summary

Opiates are the mainstay analgesics for severe pain. However, their use in pain relief can be greatly limited due to gut-related side-effects. These include chronic constipation, which is mediated through actions on neurons in the intestine. In this proposal we will examine the role of key proteins, known as beta arrestins, in the generation of opiate-induced constipation. Knowledge derived from this study will facilitate the development of analgesics with fewer gastrointestinal side-effects.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $410,594.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Autonomic Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

G-protein coupled receptors | constipation | enteric neurons | gastrointestinal motility | intestinal motility disorders | intracellular signalling | molecular pharmacology | opioid receptors | receptor trafficking

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