Understanding multidrug resistance in cancer: identification of the substrate and inhibitor binding sites in P-glycoprotein

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1049685

Funding Status
Closed

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Funded Activity Summary

Cancers expressing the multidrug transporter P-glycoprotein (P-gp) are resistant to chemotherapy. The clinical impact of P-gp is so large that the National Cancer Institute (USA) “profiles” all anticancer drugs for transport by P-gp, primarily because the mechanism of drug binding and transport by P-gp is unknown. The aim of this proposal is to understand the molecular details of how drugs bind to and interact with P-gp, a major step in our understanding of P-gp mediated chemotherapy resistance.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $284,343.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biomolecular Modelling and Design

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

P-glycoprotein | computational chemistry | drug transport | multidrug resistance | pharmacokinetics | structure-function

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