pH-dependent, antibody-mediated enhancement of genital chlamydial infection: implications for vaccine design ?

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1049571

Funding Status
Closed

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Funded Activity Summary

Antibody found in cervicovaginal secretions is predominantly of the IgG subclass. In the acidic environment of the female reproductive tract IgG antibodies against surface antigens on Chlamydia may actually enhance rather than prevent infection, due to uptake of IgG-coated bacteria by the neonatal Fc receptor (FcRn), which is found on the surface of epithelial cells in the reproductive tract. The proposed studies will determine the effects of chlamydial antibodies on the course of infection.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $373,228.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Immunology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

antibody | chlamydia | mucosal immunity | reproductive immunology | sexually-transmitted infections (STI) | vaccination immunology

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