Elucidating the role of claudin-2 in tumour initiation and metastasis development from colorectal cancer: consequence for tumour relapse

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1049561

Funding Status
Closed

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Funded Activity Summary

Mortality from colorectal cancer is often due to the development of metastases. Cancer stem cells (CSC) are suspected to provide a major drive for metastasis development, to resist current therapies, and to initiate tumour relapse. Yet, little is known about mechanisms that control CSC behaviour. Our project investigates the role of claudin-2, a cell adhesion protein that is strongly overexpressed in colorectal cancer, in the regulation of CSCs, metastasis development and tumour relapse.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $398,993.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cancer Cell Biology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

adhesion molecules | cancer cell biology | chemotherapy | colorectal cancer | metastatic progression | relapse | tumourigenesis

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