Metabolic stress sensing by AMPK: implications for energy balance and isoform-targetting therapeutics

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1049197

Funding Status
Closed

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Funded Activity Summary

Metabolic diseases such as obesity, type 2 diabetes and cardiovascular disease impose enormous medical and economic burdens on Western societies. Our research is focussed on the enzyme AMP-activated protein kinase (AMPK) which acts as the fuel gauge of the cell and is a promising drug target for combating metabolic diseases. Our discoveries provide critical insight on how AMPK is switched on by both energy demand and drugs, and will greatly assist development of AMPK-targetted therapeutics.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $632,188.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Metabolism

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

AMP-activated protein kinase | biochemistry | cardiovascular disease | diabetes | drug discovery | kinases | lipid metabolism | metabolic syndrome | obesity

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