Inhibition of Bone Resorption Increases Skeletal Mechanical Strength by Thickening Trabecular Structures

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/104910

Funding Status
Closed

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Funded Activity Summary

This project will identify the basis by which a number of therapies for osteoporosis decrease the risk of bone fractures. Currently at least four classes of these compounds in current use for the treatment of osteoporosis. Some of them have been found to have a very marked beneficial effect by halving the risk of fracture. This study will determine if each of these classes of compounds have the ability to increase the mechanical strength of bone to the same level and if each of these compounds has the same effects on bone structure. Further the effects of stimulating bone formation by subjecting the skeletal to mechanical stress, on the efficacy of each of the therapies will be established. Conversely the effect of aging, which imposes a limitation on bone formation, will be studied.

Funded Activity Details

Start Date: 01-01-2000

End Date: 01-01-2002

Funding Scheme: NHMRC Project Grants

Funding Amount: $175,648.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Orthopaedics

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

Antiresorptive therapies | Bone Histomorphometry | Bone metabolism | Health related to ageing | Menopause | Osteoporosis | Prevention of fractures | Women's Health

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