Molecular pathogenesis of herpes simplex virus latency and reactivation : relationship with viral genomic structure

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/104880

Funding Status
Closed

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Funded Activity Summary

A major target for antiviral drugs that combat herpes simplex infections, such as genital herpes and herpes encephalitis, is replication of viral DNA. There are significant gaps in the understanding of herpes simplex virus DNA replication which are addressed in this project. Further, a major factor responsible for the high impact of herpes simplex on the community is virus' ability to lie dormant (latent) in the body. The significance of lateny is that it periodically reactivates giving rise to recurrent infections. In molecular terms, latency is a reversible interruption of viral DNA replication, but the precise mechanisms involved are incompletely understood. This project explores ways in which latency might be established and reactivated. This information may eventually lead to improved strategies for reducing the burdens caused by herpes simplex virus infections.

Funded Activity Details

Start Date: 01-01-2000

End Date: 01-01-2002

Funding Scheme: NHMRC Project Grants

Funding Amount: $217,060.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Applied immunology (incl. antibody engineering xenotransplantation and t-cell therapies)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

DNA replication | Herpes simplex virus | gental herpes | herpes encephalitis | herpes simplex | latency | molecular biology | neonatal herpes | pathogenesis

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