Viral-mediated modulation of BDNF expression in motor neurons to promote the recovery of hand/digits function in a rat model of spinal cord injury that impairs normal grasping action.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1048764

Funding Status
Closed

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Funded Activity Summary

This project seeks to lure injured axons towards motor neurons, a process that is essential for the recovery of motor function. BDNF gradients will be created along the injured axons path. Axons will have to elongate to reach the first source of BDNF. They will need to elongate even more to get to the next source of BDNF, hence bringing them each time closer to their lost targets. This gene therapy scenario has the potential to bring gene therapy a step closer for human spinal cord injury.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $341,427.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Central Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

axon regeneration | axonal reconnection | brain-derived neurotrophic factor (BDNF) | gene transfer | hand function | motor recovery | nerve excitability | rat | repair | spinal cord injury

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