Capsule Synthesis and Tyrosine Phosphorylation in Streptococcus pneumoniae

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1048749

Funding Status
Closed

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Funded Activity Summary

The bacterium Streptococcus pneumoniae causes much morbidity and mortality worldwide. Antibiotic resistance and vaccination is problematic. New anti-infectives are required. We will study proteins (CpsB, CpsC, CpsD) that regulate polysaccharide capsule synthesis to understand their interactions, and to identify drugs that inhibit CpsB and CpsD. We will also investigate the wider role of tyrosine phosphorylation in the bacterium and investigate how this intersects with capsule synthesis.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $587,803.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Bacteriology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

antibiotics | bacterial infection | bacterial pathogen | infectious diseases | molecular microbiology

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