Identification of the Mechanisms of Hepatic Fibrogenesis Aid in the Detection and Prediction of Clinical Outcomes in Paediatric Cholestatic Liver Disease.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1048740

Funding Status
Closed

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Funded Activity Summary

Biliary Atresia (BA) and Cystic Fibrosis Liver Disease (CFLD) are important causes of childhood cirrhosis. Diagnosis is difficult, treatments problematic, and outcomes suboptimal. In BA, bile duct obstruction in infants rapidly progresses to liver failure. It is the most common indication for liver transplantation in children. CFLD causes significant morbidity/mortality in about 20% of CF children. This proposal investigates the mechanisms of liver fibrosis (scarring) and the role of fibrosis in both diagnosis and predicting clinical outcome.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $624,429.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Gastroenterology and Hepatology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

biliary atresia | cirrhosis | cystic fibrosis | hepatic fibrosis | hepatic stellate cells

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