Enhancing the neuroprotective benefit of hypothermia with melatonin in the asphyxiated neonate

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1048039

Funding Status
Closed

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Funded Activity Summary

During labour, asphyxic episodes which cause a severe reduction in oxygen supply can become prolonged and result in perinatal brain injury, termed Hypoxic Ischemic Encephalopathy, which may underlie cerebral palsy. Presently, newborn infants with suspected encephalopathy are cooled, which modestly protects the brain against cellular injury. We propose that the administration of melatonin to the newborn, in addition to cooling, will decrease the post-asphyxic formation of oxygen free radicals, thereby reducing the progression of brain damage.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $785,331.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Paediatrics

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

birth asphyxia | brain injury | cerebral palsy treatments | hypoxia-ischaemia-reperfusion injury | neuroprotection

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