Development of new anticancer drugs using sortase-mediated ligation

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1047857

Funding Status
Closed

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Funded Activity Summary

There is a great need for new cancer treatments. We are developing cyclic peptides as the next generation of safe and effective cancer drugs. Cyclic peptides, unlike their linear counterparts, display high stability and oral bioavailability, as well as high solubility and negligible immune response. One of the hurdles is the cyclisation process and we aim to develop enzyme-mediated cyclisation as a convenient and cost effective method for cyclic peptide production.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $618,274.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Proteins and Peptides

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cancer treatment | enzyme mechanism | nuclear magnetic resonance (NMR) spectroscopy | peptide synthesis | protein expression | protein oxidation

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