Modulation of telomere length and subtelomeric DNA methylation in response to oxidative stress in the male germ line; implications for tumorigenesis in the offspring

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1047776

Funding Status
Closed

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Funded Activity Summary

This research project is designed to elucidate how the quality of a father’s spermatozoa can impact upon the health and wellbeing of his children. We hypothesize that factors, such as infertility, heavy smoking or age create a state of oxidative stress in the testes and that this stress influences the genetic structure of spermatozoa in such a way that the incidence of spontaneous mutations and susceptibility-to-cancer are significantly elevated in the offspring.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $310,684.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Reproduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

embryonic development | oxidative stress | sperm function | spermatogenesis | telomeres

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