The role of natural protein inhibitors in blocking breast cancer invasion

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1047748

Funding Status
Closed

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Funded Activity Summary

The mechanisms required for breast cancer cells to spread outside of the ducts and into the surrounding breast tissue are largely unknown. There is increasing evidence that the cell layer surrounding the ducts (myoepithelium) functions to suppress invasion. We aim to test if a protein inhibitor that is expressed in these cells can preventing breast cancer invasion in models of early breast cancer and if its expression can predict those patients that are unlikely to develop invasive cancers.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $424,139.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cancer Cell Biology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

breast cancer | cell-cell communication | invasion | mouse models | protease inhibitors

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