Dissecting the role of insulin-regulated phosphorylation of Rab guanine nucleotide exchange factors in GLUT4 trafficking

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1047067

Funding Status
Closed

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Funded Activity Summary

Diabetes and obesity are epidemic in the developed world. Impaired insulin action is a major cause. A key contributor is reduced glucose uptake into muscle and fat driving the pancreas to overproduce insulin. We have recently discovered three new molecules that we believe hold the secret to how insulin regulates the removal of the glucose from the blood stream after a meal. This proposal focuses on these three molecules and their regulation.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $628,459.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

GTPase | cell biology | glucose transporters | insulin action | insulin signalling | mass spectrometry | protein phosphorylation | protein trafficking | signal transduction | vesicle transport

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