Targeting TRPV4 activation mechanisms to reveal novel pain therapies

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1046860

Funding Status
Closed

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Funded Activity Summary

Pain nerves sense painful chemical and physical stimuli, by opening protein "ion channels" which let small electric currents traverse the cell membrane. This pain signal is transmitted to the spinal cord and then the brain, where it is perceived as pain and elicits a reaction. But we don't know how the ion channels open. This project will investigate how receptors for painful substances open ion channels to cause pain. Understanding this mechanism will help us to make new drugs to treat pain.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $580,938.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Basic Pharmacology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

G-protein coupled receptors | Src-family tyrosine kinases | chronic pain | intracellular calcium | intracellular signal transduction | ion channels | protein phosphorylation

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